Neonatal stroke

A neonatal stroke is one that occurs in the first 28 days of life, though a late presentation is not uncommon (as contrasted with perinatal stroke, which occurs from 28 weeks gestation through the first 7 days of life

  • 80% of neonatal strokes are ischemic, and their presentation is varied, making diagnosis very difficult
  • The most common manifestation of neonatal strokes are seizures, but other manifestations include lethargy, hypotonia, apnoea, and hemiparesis
  • Seizures can be focal or generalized in nature.
  • Stroke accounts for about 10% of seizures in term neonates

Many different risk factors play a role in causing a neonatal stroke. Some maternal disorders that may contribute to neonatal strokes include: autoimmune disorders, coagulation disorders, prenatal cocaine exposure, infection, congenital heart disease diabetes, and trauma.

 Placental disorders that increase the risk of stroke include placental thrombosis, placental abruption, placental infection, and chorioamnionitis.

 Other disorders that may increase the risk of a neonatal stroke are blood, homocysteine and lipid disorders, such as polycythemia, disseminated intravascular coagulopathy, prothrombin mutation, lipoprotein (a) deficiency, factor VIII deficiency (hemophilia A), and factor V Leiden mutation.

 Infectious disorders such as central nervous system (CNS) infection or systemic infection may also contribute.



  • Disorders that Increase Risk of Neonatal Stroke
  • Diagnosis of Neonatal Stroke
  • treatment of stroke
  • Therapeutic Hypothermia
  • Supraventricular tachycardia

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